okay - opened a ticket and link to here.
Btw. I cannot see any setup remotes anymore under Settings -> Remotes.

When I am adding a new one, it just vanishes upon saving.

olivierlambert this is not really an option right now. Do you guys have any guesses on what could cause the issue?

syslog while taking a backup:

Oct 8 04:36:41 xoa netdata: EXIT: all done - netdata is now exiting - bye bye...
Oct 8 04:36:41 xoa netdata[83536]: 2020-10-08 04:36:41: netdata INFO : MAIN : EXIT: all done - netdata is now exiting - bye bye...
Oct 8 04:36:41 xoa systemd[1]: netdata.service: Main process exited, code=exited, status=1/FAILURE
Oct 8 04:36:41 xoa systemd[1]: netdata.service: Failed with result 'exit-code'.
Oct 8 04:36:44 xoa xo-server[123232]: 2020-10-08T08:36:44.360Z xo:api WARN crp | backupNg.runJob(...) [83ms] =!> TypeError: Invalid attempt to destructure non-iterable instance.
Oct 8 04:36:44 xoa xo-server[123232]: In order to be iterable, non-array objects must have a Symbol.iterator method.
Oct 8 04:36:46 xoa systemd[1]: netdata.service: Service RestartSec=5s expired, scheduling restart.
Oct 8 04:36:46 xoa systemd[1]: netdata.service: Scheduled restart job, restart counter is at 2276722.
Oct 8 04:36:46 xoa systemd[1]: Stopped netdata real-time system monitoring.
Oct 8 04:36:46 xoa systemd[1]: Started netdata real-time system monitoring.
Oct 8 04:36:46 xoa netdata: Cannot cd to directory '/var/cache/netdata'

syslog
ct 8 04:32:24 xoa systemd[1]: netdata.service: Main process exited, code=exited, status=1/FAILURE
Oct 8 04:32:24 xoa netdata: Cleaning up database [0 hosts(s)]...
Oct 8 04:32:24 xoa systemd[1]: netdata.service: Failed with result 'exit-code'.
Oct 8 04:32:24 xoa netdata: EXIT: all done - netdata is now exiting - bye bye...
Oct 8 04:32:29 xoa systemd[1]: netdata.service: Service RestartSec=5s expired, scheduling restart.
Oct 8 04:32:29 xoa systemd[1]: netdata.service: Scheduled restart job, restart counter is at 2276672.
Oct 8 04:32:29 xoa systemd[1]: Stopped netdata real-time system monitoring.
Oct 8 04:32:29 xoa systemd[1]: Started netdata real-time system monitoring.
Oct 8 04:32:29 xoa netdata: Cannot cd to directory '/var/cache/netdata'
Oct 8 04:32:29 xoa netdata[82958]: 2020-10-08 04:32:29: netdata FATAL : MAIN :Cannot cd to directory '/var/cache/netdata' # : No such file or directory
Oct 8 04:32:29 xoa netdata[82958]: 2020-10-08 04:32:29: netdata INFO : MAIN : EXIT: netdata prepares to exit with code 1...
Oct 8 04:32:29 xoa netdata[82958]: 2020-10-08 04:32:29: netdata INFO : MAIN : EXIT: cleaning up the database...
Oct 8 04:32:29 xoa netdata[82958]: 2020-10-08 04:32:29: netdata INFO : MAIN : Cleaning up database [0 hosts(s)]...
Oct 8 04:32:29 xoa netdata[82958]: 2020-10-08 04:32:29: netdata INFO : MAIN : EXIT: all done - netdata is now exiting - bye bye...
Oct 8 04:32:29 xoa systemd[1]: netdata.service: Main process exited, code=exited, status=1/FAILURE
Oct 8 04:32:29 xoa netdata: EXIT: netdata prepares to exit with code 1...
Oct 8 04:32:29 xoa systemd[1]: netdata.service: Failed with result 'exit-code'.
Oct 8 04:32:29 xoa netdata: EXIT: cleaning up the database...
Oct 8 04:32:29 xoa netdata: Cleaning up database [0 hosts(s)]...
Oct 8 04:32:29 xoa netdata: EXIT: all done - netdata is now exiting - bye bye...

Node version
xo-server config syntax
Disk space for /
Disk space for /var
Native SMB support
Fetching VM UUID
XOA version
Appliance registration
Internet connectivity
npm version
XOA status

{
npm: '4.6.1',
ares: '1.16.0',
brotli: '1.0.7',
cldr: '37.0',
http_parser: '2.9.3',
icu: '67.1',
llhttp: '2.0.4',
modules: '72',
napi: '6',
nghttp2: '1.41.0',
node: '12.18.2',
openssl: '1.1.1g',
tz: '2019c',
unicode: '13.0',
uv: '1.38.0',
v8: '7.8.279.23-node.39',
zlib: '1.2.11'
}

Hi it's a XOA VM, so I do not know the specifics at this moment.
I'll log into the machine and try to get the data.

After upgrade to 5.50.3 I cannot perform any backups.

Backup jobs fail immediately with this error message:

Invalid attempt to destructure non-iterable instance.
In order to be iterable, non-array objects must have a Symbol.iterator method.