@ronan-a we need to have CBT to use 3rd party backup & replication solution such as Veeam.
On the other hand, XOSTOR with VHD disk might be ok using Xen Orchestra backup & replication features but it needs more testing on our end to make sure it works good enough.
One big question is about the snapshot chain. Coming from VMware world where keeping snapshots may impact I/O performances, we're not very comfortable with it.
Also, we need to find solution for low-RPO replication. On our VMware infrastructure we use Zerto DR for this but XOA being more like Veeam using snapshots, low-RPO will be tough to achieve (unless making snapshots doesn't affect performances at all ?).